- Sally Hawkins Elisa Esposito
- Michael Shannon Richard Strickland
- Richard Jenkins Giles
- Doug Jones Hombre anfibio
- Michael Stuhlbarg Dr. Robert Hoffstetler
- Octavia Spencer Zelda Fuller
- Lauren Lee Smith Elaine
- David Hewlett Fleming
- John Kapelos Mr. Arzounian
- Nick Searcy Hoyt