- Frances McDormand Mildred Hayes
- Woody Harrelson Sheriff Bill Willoughby
- Sam Rockwell Oficial Jason Dixon
- Peter Dinklage James
- Abbie Cornish Anne Willoughby
- Caleb Landry Jones Red
- Kerry Condon
- John Hawkes Charlie
- Lucas Hedges Robbie Hayes
- Zeljko Ivanek
- Brendan Sexton III Crop Haired Man
- Nick Searcy Padre Montgomery
- Marcus Lyle Brown Periodista
- Kathryn Newton Angela
- Samara Weaving Penelope
- Clarke Peters Abercrombie