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- Chris Pine Dr. Alex Murry
- Gugu Mbatha-Raw Dr. Kate Murry
- Zach Galifianakis The Happy Medium
- Michael Peña Red
- Mindy Kaling Sra. Who
- Levi Miller Calvin
- Oprah Winfrey Sra. Which
- André Holland Principal Jenkins
- Will McCormack
- Storm Reid Meg Murry