- Dwayne Johnson Davis Okoye
- Naomie Harris Dr. Kate Caldwell
- Malin Akerman Claire Wyden
- Jeffrey Dean Morgan Agente Russell
- Jake Lacy Brett Wyden
- Joe Manganiello Burke
- Marley Shelton Dr. Kerry Atkins
- P.J. Byrne Nelson
- Demetrius Grosse Coronel Blake
- Jack Quaid Connor
- Matt Gerald Zammit
- Will Yun Lee Agente Park
- Jason Liles George