- Amy Schumer Renee Barrett
- Michelle Williams Avery LeClair
- Rory Scovel Ethan
- Emily Ratajkowski Mallory
- Busy Philipps Jane
- Aidy Bryant Vivian
- Tom Hopper Grant LeClair
- Naomi Campbell Helen
- Lauren Hutton Lily LeClair
- Adrian Martinez Mason
- Kevin Kane Chico en la farmacia