- Antonio Banderas Gregorio Cortez
- Carla Gugino Ingrid Cortez
- Alexa Vega Carmen Cortez
- Daryl Sabara Juni Cortez
- Sylvester Stallone Toymaker
- Ricardo Montalbán Abuelo
- Salma Hayek Dora
- Holland Taylor Abuela
- Danny Trejo Machete
- Bobby Edner Francis The Brain
- Ryan Pinkston Arnold
- Robert Vito Rez
- Courtney Jines Demetra
- Steve Buscemi Romero
- George Clooney Devlin
- Alan Cumming Fegan Floop
- Mike Judge Donnagon Giggles
- Matthew O'Leary Gary Giggles
- Emily Osment Gerti Giggles
- Bill Paxton Dinky Winks
- Matt O'Leary Gary Giggles
- Selena Gomez
- Glen Powell
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